Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).

σ1:860 nM

Blarcamesine(1/3 mg/kg) 的预处理依剂量降低由东莨菪碱引起的交替缺陷。Blarcamesine(>0.3 mg/kg) 的预处理依剂量显著减轻了穿越潜伏期的损害[1]。Blarcamesine(1mg/kg) 依剂量阻断认知记忆缺陷。注射后一天，显着的Aβ25-35引起的Akt磷酸化降低被Blarcamesine(0.1/1mg/kg) 显著减轻。注射后七天，Blarcamesine减轻了由该肽体 (0.3/1mg/kg) 引起的Ser9磷酸化减少[2]。

Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures.